Lighting Up Individual DNA Binding Proteins with Quantum Dots

Supporting information Lighting up individual transcription factors with quantum dots

Lighting up cells with quantum dots.

Quantum dots are a brand new class of fluorescent biolabeling reagents. These nanometer-sized semiconductor crystals can be attached to biomolecules and can be used in many existing immunostaining applications. Recent work has demonstrated the dramatic benefits of quantum dots, including long-term photostability, high brightness, multi-target labeling with several colors, and single-source exci...

Lighting up micromotors with quantum dots for smart chemical sensing.

A new "on-the-fly" chemical optical detection strategy based on the incorporation of fluorescence CdTe quantum dots (QDs) on the surface of self-propelled tubular micromotors is presented. The motion-accelerated binding of trace Hg to the QDs selectively quenches the fluorescence emission and leads to an effective discrimination between different mercury species and other co-existing ions.

Tracking individual membrane proteins using quantum dots.

Single-particle tracking of individual membrane molecules is now the method of choice to decipher the molecular organization of the plasma membrane. By labeling proteins or lipids with latex beads, 40-nm gold nanoparticles, or small organic fluorophores, it is possible to analyze the mechanisms controlling their lateral dynamics. Semiconductor quantum dots (QDs) provide several advantages for t...

Quantum dots, lighting up the research and development of nanomedicine.

UNLABELLED Quantum dots (QDs) have proven themselves as powerful inorganic fluorescent probes, especially for long term, multiplexed imaging and detection. The newly developed QDs labeling techniques have facilitated the study of drug delivery on the level of living cells and small animals. Moreover, based on QDs and fluorescence imaging system, multifunctional nanocomplex integrated targeting,...